Hello Friend,

Welcome to Friday! 

Classic Far Side.. :-)



Things change in veterinary medicine, and with so much information, your veterinarian can't always stay up on it- in fact it's somewhat up to you..

One resource you should have is the 67 step by step videos, Complete Remedy Manual, First Aid Manual, and weekly updates ALL in my Inner Circle

 Here:

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Anesthetic reactions your Vet may not be aware of...
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One veterinary journal I regularly read called 'Clinicians Brief' recently published a paper on Breed Specific Anesthesia. That is certain breeds can react very differently to certain types of anesthetic.

If you have a herding breed ( ie Collie, Shetland Sheepdog), then there are a few things you should know about.

This is part of the article: ( Breed-Specific Anesthesia
Stephanie Krein, DVM, & Lois A. Wetmore, DVM, ScD, DACVA Tufts University)


These breeds have a high prevalence (eg, up to 75% in collies in the United States) for genetic mutation in the ABCB1 (formerly MDR1) gene.8,9 ABCB1 encodes P-glycoprotein, an adenosine triphosphate–driven pump that is an integral component of the blood–brain barrier and provides protection from toxic drug accumulation in body fluids, such as cerebrospinal fluid (CSF).

 In the collie and other herding breeds, this genetic mutation results in a defective pump that allows a select group of drugs to accumulate within the brain.


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These are the anesthetic drugs that need to be watched
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Acepromazine and opioids, particularly butorphanol, are members of this drug group, and their accumulation in CSF may cause marked sedation and respiratory depression. When using these agents in susceptible breeds, the dose should be decreased by 25% and patients closely monitored for side effects.



Heal Your Pet At Home!

Best Wishes,

Dr Andrew Jones, DVM


P.S. I regularly used Acepromazine, and the opiods in practice, and I don't recall reducing the doses by 25% for the herding breeds. If you have a herding breed, ask your veterinarian if they use Acepromazine, and any of the opiods in their pre-med ( that is the 1st part of the anesthetic given as a sedative).

It's very common.

If so bring up the article- and ensure that they reduce the dose.


P.P.S. As you can see, there are MANY things to stay on top of, never mind holistic options

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P.P.P.S. Have a Great weekend!

DISCLAIMER: This information is for educational purposes only and is not intended to replace the advice of your own veterinarian. Dr Andrew Jones resigned from the College of Veterinarians of B.C. effective December 1 2010, meaning he cannot answer specific questions about your pet's medical issues or make specific medical recommendations for your pet.

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